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Susan J. Little, MD
Associate Professor of Medicine
Background
Susan J. Little, M.D. is an Associate Professor of Medicine in the Department of Medicine, Division of Infectious Diseases, at the University of California, San Diego (UCSD). Dr. Little received her medical degree in 1987 from the Washington University School of Medicine, and then did her residency in Internal Medicine at Barnes Hospital in St. Louis, Missouri. She then completed an Infectious Diseases fellowship at UCSD.
Since joining the UCSD faculty in 1993, Dr. Little has developed one of the leading and most productive National Institute of Allergy and Infectious Diseases (NIAID)-sponsored programs in the United States for the identification, enrollment, and treatment of individuals with acute and recent HIV-1 infection. She directs the Clinical Core of the Acute Infection and Early Disease Research Program (AIEDRP) at UCSD, and oversees the integration of pathogenesis, translational, and clinical research in the UCSD Acute and Early HIV Infection (AEH) Program. Dr. Little is currently Co-Chair of the HIV Prevention Science Committee, a joint committee of the HIV Prevention Trials Network (HPTN) and the AIDS Clinical Trials Group (ACTG).
Dr. Little has published extensively in peer-reviewed journals and serves on the Editorial Boards of the Journal of Acquired Immune Deficiency Syndromes (JAIDS) and Antiviral Therapy. She has been invited to present her work at numerous international meetings, including the Conference on Retroviruses and Opportunistic Infections, the International HIV Drug Resistance Workshop, and the Infectious Diseases Society of America, and serves on the scientific committees of the International HIV Drug Resistance Workshop and the World Health Organization HIV Resistance Network (HIVResNet).
Research Interests
Dr. Little conducts translational research and clinical trials to increase our understanding of the pathogenesis of acute or primary HIV infection and HIV transmission, and works with a large international collaborative team to assess viral replication dynamics and host immune dynamics during acute HIV infection. These studies also evaluate therapeutic intervention strategies, including antiretroviral therapy and vaccines to preserve immune function in recently infected subjects. Dr. Little is an active investigator in the UCSD unit of the AIDS Clinical Trials Group (ACTG, funded by the National Institutes of Health), and has developed numerous ACTG and AIEDRP protocols to evaluate new strategies for treatment of acute infection. She has been heavily involved in the design of novel approaches to screen and identify acutely infected individuals, as well as the evaluation of important pathogenesis questions related to development of drug resistant variants in genital secretions and transmission of drug-resistant HIV-1.
Selected Publications
1. Little S, McLean AR, Spina CA, Richman DD, Havlir DV. Viral dynamics of acute HIV-1 infection. J Exp Med 1999;190(6):841-850.
2. Little SJ, Daar ES, D’Aquila RT, Keiser PH, Connick E, Whitcomb JM, Hellmann NS, Petropoulos CJ, Sutton L, Pitt JA, Rosenberg ES, Koup RA, Walker BD, Richman DD. Reduced antiretroviral drug susceptibility among patients with primary HIV infection. JAMA 1999;282(12):1142-1149.
3. Little SJ, Holte S, Routy J-P, Daar ES, Markowitz M, Collier AC, Koup RA, Mellors JW, Connick E, Conway B, Kilby M, Whitcomb JM, Hellmann NS, Richman DD. Antiretroviral drug resistance among subjects recently infected with HIV. New Engl J Med 2002;347(6):385-394.
4. Leigh Brown AJ, Frost SDW, Mathews WC, Dawson K, Hellmann NS, Daar ES, Richman DD, Little SJ. Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population. J Infect Dis 2003;187(4):683-686.
5. Smith DM, Wong JK, Hightower GK, Ignacio CC, Koelsch KK, Daar ES, Richman DD, Little SJ. Incidence of HIV superinfection following primary infection. JAMA 2004; 292(10):1177-1178.
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